{"id":348,"date":"2021-06-30T17:34:23","date_gmt":"2021-06-30T17:34:23","guid":{"rendered":"https:\/\/groningenmicrobiome.org\/?p=348"},"modified":"2021-10-12T08:27:10","modified_gmt":"2021-10-12T08:27:10","slug":"exploring-the-microbiome-genetics-in-dmp","status":"publish","type":"post","link":"https:\/\/groningenmicrobiome.org\/?p=348","title":{"rendered":"Exploring the microbiome-genetics in the DMP"},"content":{"rendered":"\n

The results of genome-wide association study of effect of host genetics on gut microbiome in the Dutch Microbiome Project cohort are now available on BioRxiv<\/a>! We studied 207 taxa and 205 pathways from gut microbiomes of 7,738 participants in the Dutch Microbiome Project<\/a>, a cohort from the Northern Netherlands. We found two obust, study-wide significant (p<\/em><1.89\u00d710\u221210<\/sup>) signals near the LCT<\/em> and ABO<\/em> genes were found to affect multiple microbial taxa and pathways, and replicated these results in two independent cohorts. <\/p>\n\n\n\n

We found that the LCT<\/em>\u00a0locus associations are modulated by host’s lactose intake, while those at\u00a0ABO<\/em>\u00a0reflected participant secretor status determined by\u00a0FUT2<\/em>\u00a0genotype. Eighteen other loci showed suggestive evidence (p<\/em><5\u00d710\u22128<\/sup>) of association with microbial taxa and pathways. Summary statistics are available on our DMP website<\/a>.<\/p>\n\n\n\n

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Brief overview of microbiome-host genetics GWAS, see manuscript <\/a>for details<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"

The results of genome-wide association study of effect of host genetics on gut microbiome in the Dutch Microbiome Project cohort are now available on BioRxiv! We studied 207 taxa and 205 pathways from gut microbiomes of 7,738 participants in the Dutch Microbiome Project, a cohort from the Northern Netherlands. We found two obust, study-wide significant […]<\/p>\n","protected":false},"author":2,"featured_media":1119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[4],"tags":[9,8],"class_list":["post-348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-genetics","tag-microbiome"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t